Compile Data Set for Download or QSAR
Found 43 of ic50 data for polymerid = 294
TargetRAF proto-oncogene serine/threonine-protein kinase [1-324](Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM202665(US10245267, Example 10 | US10709712, Example 10 | ...)copy SMILEScopy InChI
Affinity DataIC50: 0.118nMpH: 7.5 T: 2°CAssay Description:Final assay conditions were 4 pM cRaf, 3 uM ATP, 10 nM biotin tagged MEK1 kinase dead protein substrate. Reactions were performed in Greiner384 well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VT1QXTUS Patent
TargetRAF proto-oncogene serine/threonine-protein kinase [1-324](Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM202665(US10245267, Example 10 | US10709712, Example 10 | ...)copy SMILEScopy InChI
Affinity DataIC50: 0.120nMpH: 7.5 T: 2°CAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2x final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MC8X6WUS Patent
TargetRAF proto-oncogene serine/threonine-protein kinase [1-324](Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM202696(US10245267, Example 43 | US10709712, Example 42 | ...)copy SMILEScopy InChI
Affinity DataIC50: 0.137nMpH: 7.5 T: 2°CAssay Description:Final assay conditions were 4 pM cRaf, 3 uM ATP, 10 nM biotin tagged MEK1 kinase dead protein substrate. Reactions were performed in Greiner384 well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VT1QXTUS Patent
TargetRAF proto-oncogene serine/threonine-protein kinase [1-324](Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM202656(US10245267, Example 1 | US10709712, Example 1 | US...)copy SMILEScopy InChI
Affinity DataIC50: 0.140nMpH: 7.5 T: 2°CAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2x final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MC8X6WUS Patent
TargetRAF proto-oncogene serine/threonine-protein kinase [1-324](Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM202696(US10245267, Example 43 | US10709712, Example 42 | ...)copy SMILEScopy InChI
Affinity DataIC50: 0.140nMpH: 7.5 T: 2°CAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2x final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MC8X6WUS Patent
TargetRAF proto-oncogene serine/threonine-protein kinase [1-324](Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM202656(US10245267, Example 1 | US10709712, Example 1 | US...)copy SMILEScopy InChI
Affinity DataIC50: 0.144nMpH: 7.5 T: 2°CAssay Description:Final assay conditions were 4 pM cRaf, 3 uM ATP, 10 nM biotin tagged MEK1 kinase dead protein substrate. Reactions were performed in Greiner384 well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VT1QXTUS Patent
TargetRAF proto-oncogene serine/threonine-protein kinase [1-324](Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM202772(US10245267, Example 119 | US10709712, Example 119 ...)copy SMILEScopy InChI
Affinity DataIC50: 0.270nMpH: 7.5 T: 2°CAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2x final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MC8X6WUS Patent
TargetRAF proto-oncogene serine/threonine-protein kinase [1-324](Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM202772(US10245267, Example 119 | US10709712, Example 119 ...)copy SMILEScopy InChI
Affinity DataIC50: 0.270nMpH: 7.5 T: 2°CAssay Description:Final assay conditions were 4 pM cRaf, 3 uM ATP, 10 nM biotin tagged MEK1 kinase dead protein substrate. Reactions were performed in Greiner384 well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VT1QXTUS Patent
TargetRAF proto-oncogene serine/threonine-protein kinase [1-324](Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM202771(US10245267, Example 118 | US10709712, Example 118 ...)copy SMILEScopy InChI
Affinity DataIC50: 0.308nMpH: 7.5 T: 2°CAssay Description:Final assay conditions were 4 pM cRaf, 3 uM ATP, 10 nM biotin tagged MEK1 kinase dead protein substrate. Reactions were performed in Greiner384 well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VT1QXTUS Patent
TargetRAF proto-oncogene serine/threonine-protein kinase [1-324](Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM202771(US10245267, Example 118 | US10709712, Example 118 ...)copy SMILEScopy InChI
Affinity DataIC50: 0.310nMpH: 7.5 T: 2°CAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2x final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MC8X6WUS Patent
TargetRAF proto-oncogene serine/threonine-protein kinase [1-324](Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM202697(US10245267, Example 42 | US10709712, Example 43 | ...)copy SMILEScopy InChI
Affinity DataIC50: 0.376nMpH: 7.5 T: 2°CAssay Description:Final assay conditions were 4 pM cRaf, 3 uM ATP, 10 nM biotin tagged MEK1 kinase dead protein substrate. Reactions were performed in Greiner384 well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VT1QXTUS Patent
TargetRAF proto-oncogene serine/threonine-protein kinase [1-324](Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM202718(US10245267, Example 111 | US10709712, Example 111 ...)copy SMILEScopy InChI
Affinity DataIC50: 0.400nMpH: 7.5 T: 2°CAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2x final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MC8X6WUS Patent
TargetRAF proto-oncogene serine/threonine-protein kinase [1-324](Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM202764(US10245267, Example 64 | US10709712, Example 64 | ...)copy SMILEScopy InChI
Affinity DataIC50: 0.403nMpH: 7.5 T: 2°CAssay Description:Final assay conditions were 4 pM cRaf, 3 uM ATP, 10 nM biotin tagged MEK1 kinase dead protein substrate. Reactions were performed in Greiner384 well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VT1QXTUS Patent
TargetRAF proto-oncogene serine/threonine-protein kinase [1-324](Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM202661(US10245267, Example 6 | US10709712, Example 6 | US...)copy SMILEScopy InChI
Affinity DataIC50: 0.408nMpH: 7.5 T: 2°CAssay Description:Final assay conditions were 4 pM cRaf, 3 uM ATP, 10 nM biotin tagged MEK1 kinase dead protein substrate. Reactions were performed in Greiner384 well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VT1QXTUS Patent
TargetRAF proto-oncogene serine/threonine-protein kinase [1-324](Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM202661(US10245267, Example 6 | US10709712, Example 6 | US...)copy SMILEScopy InChI
Affinity DataIC50: 0.410nMpH: 7.5 T: 2°CAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2x final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MC8X6WUS Patent
TargetRAF proto-oncogene serine/threonine-protein kinase [1-324](Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM202845(US10245267, Example 198 | US10709712, Example 198 ...)copy SMILEScopy InChI
Affinity DataIC50: 0.455nMpH: 7.5 T: 2°CAssay Description:Final assay conditions were 4 pM cRaf, 3 uM ATP, 10 nM biotin tagged MEK1 kinase dead protein substrate. Reactions were performed in Greiner384 well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VT1QXTUS Patent
TargetRAF proto-oncogene serine/threonine-protein kinase [1-324](Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM202845(US10245267, Example 198 | US10709712, Example 198 ...)copy SMILEScopy InChI
Affinity DataIC50: 0.460nMpH: 7.5 T: 2°CAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2x final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MC8X6WUS Patent
TargetRAF proto-oncogene serine/threonine-protein kinase [1-324](Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM202717(US10245267, Example 63 | US10709712, Example 63 | ...)copy SMILEScopy InChI
Affinity DataIC50: 0.508nMpH: 7.5 T: 2°CAssay Description:Final assay conditions were 4 pM cRaf, 3 uM ATP, 10 nM biotin tagged MEK1 kinase dead protein substrate. Reactions were performed in Greiner384 well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VT1QXTUS Patent
TargetRAF proto-oncogene serine/threonine-protein kinase [1-324](Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM202717(US10245267, Example 63 | US10709712, Example 63 | ...)copy SMILEScopy InChI
Affinity DataIC50: 0.510nMpH: 7.5 T: 2°CAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2x final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MC8X6WUS Patent
TargetRAF proto-oncogene serine/threonine-protein kinase [1-324](Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM202663(US10709712, Example 8 | US9242969, 8 | US9242969, ...)copy SMILEScopy InChI
Affinity DataIC50: 0.510nMpH: 7.5 T: 2°CAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2x final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MC8X6WUS Patent
TargetRAF proto-oncogene serine/threonine-protein kinase [1-324](Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM202663(US10709712, Example 8 | US9242969, 8 | US9242969, ...)copy SMILEScopy InChI
Affinity DataIC50: 0.514nMpH: 7.5 T: 2°CAssay Description:Final assay conditions were 4 pM cRaf, 3 uM ATP, 10 nM biotin tagged MEK1 kinase dead protein substrate. Reactions were performed in Greiner384 well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VT1QXTUS Patent
TargetRAF proto-oncogene serine/threonine-protein kinase [1-324](Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM202668(US10245267, Example 13 | US10709712, Example 13 | ...)copy SMILEScopy InChI
Affinity DataIC50: 0.530nMpH: 7.5 T: 2°CAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2x final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MC8X6WUS Patent
TargetRAF proto-oncogene serine/threonine-protein kinase [1-324](Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM202668(US10245267, Example 13 | US10709712, Example 13 | ...)copy SMILEScopy InChI
Affinity DataIC50: 0.533nMpH: 7.5 T: 2°CAssay Description:Final assay conditions were 4 pM cRaf, 3 uM ATP, 10 nM biotin tagged MEK1 kinase dead protein substrate. Reactions were performed in Greiner384 well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VT1QXTUS Patent
TargetRAF proto-oncogene serine/threonine-protein kinase [1-324](Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM202666(US10245267, Example 11 | US10709712, Example 11 | ...)copy SMILEScopy InChI
Affinity DataIC50: 0.580nMpH: 7.5 T: 2°CAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2x final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MC8X6WUS Patent
TargetRAF proto-oncogene serine/threonine-protein kinase [1-324](Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM202666(US10245267, Example 11 | US10709712, Example 11 | ...)copy SMILEScopy InChI
Affinity DataIC50: 0.580nMpH: 7.5 T: 2°CAssay Description:Final assay conditions were 4 pM cRaf, 3 uM ATP, 10 nM biotin tagged MEK1 kinase dead protein substrate. Reactions were performed in Greiner384 well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VT1QXTUS Patent
TargetRAF proto-oncogene serine/threonine-protein kinase [1-324](Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM202843(US10245267, Example 196 | US10709712, Example 196 ...)copy SMILEScopy InChI
Affinity DataIC50: 0.620nMpH: 7.5 T: 2°CAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2x final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MC8X6WUS Patent
TargetRAF proto-oncogene serine/threonine-protein kinase [1-324](Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM202843(US10245267, Example 196 | US10709712, Example 196 ...)copy SMILEScopy InChI
Affinity DataIC50: 0.621nMpH: 7.5 T: 2°CAssay Description:Final assay conditions were 4 pM cRaf, 3 uM ATP, 10 nM biotin tagged MEK1 kinase dead protein substrate. Reactions were performed in Greiner384 well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VT1QXTUS Patent
TargetRAF proto-oncogene serine/threonine-protein kinase [1-324](Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM202698(US10245267, Example 44 | US10709712, Example 44 | ...)copy SMILEScopy InChI
Affinity DataIC50: 0.710nMpH: 7.5 T: 2°CAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2x final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MC8X6WUS Patent
TargetRAF proto-oncogene serine/threonine-protein kinase [1-324](Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM202698(US10245267, Example 44 | US10709712, Example 44 | ...)copy SMILEScopy InChI
Affinity DataIC50: 0.714nMpH: 7.5 T: 2°CAssay Description:Final assay conditions were 4 pM cRaf, 3 uM ATP, 10 nM biotin tagged MEK1 kinase dead protein substrate. Reactions were performed in Greiner384 well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VT1QXTUS Patent
TargetRAF proto-oncogene serine/threonine-protein kinase [1-324](Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM202669(US10245267, Example 14 | US10709712, Example 14 | ...)copy SMILEScopy InChI
Affinity DataIC50: 0.800nMpH: 7.5 T: 2°CAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2x final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MC8X6WUS Patent
TargetRAF proto-oncogene serine/threonine-protein kinase [1-324](Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM202669(US10245267, Example 14 | US10709712, Example 14 | ...)copy SMILEScopy InChI
Affinity DataIC50: 0.803nMpH: 7.5 T: 2°CAssay Description:Final assay conditions were 4 pM cRaf, 3 uM ATP, 10 nM biotin tagged MEK1 kinase dead protein substrate. Reactions were performed in Greiner384 well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VT1QXTUS Patent
TargetRAF proto-oncogene serine/threonine-protein kinase [1-324](Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM202718(US10245267, Example 111 | US10709712, Example 111 ...)copy SMILEScopy InChI
Affinity DataIC50: 0.847nMpH: 7.5 T: 2°CAssay Description:Final assay conditions were 4 pM cRaf, 3 uM ATP, 10 nM biotin tagged MEK1 kinase dead protein substrate. Reactions were performed in Greiner384 well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VT1QXTUS Patent
TargetRAF proto-oncogene serine/threonine-protein kinase [1-324](Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM202764(US10245267, Example 64 | US10709712, Example 64 | ...)copy SMILEScopy InChI
Affinity DataIC50: 0.850nMpH: 7.5 T: 2°CAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2x final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MC8X6WUS Patent
TargetRAF proto-oncogene serine/threonine-protein kinase [1-324](Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM202663(US10709712, Example 8 | US9242969, 8 | US9242969, ...)copy SMILEScopy InChI
Affinity DataIC50: 0.899nMpH: 7.5 T: 2°CAssay Description:Final assay conditions were 4 pM cRaf, 3 uM ATP, 10 nM biotin tagged MEK1 kinase dead protein substrate. Reactions were performed in Greiner384 well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VT1QXTUS Patent
TargetRAF proto-oncogene serine/threonine-protein kinase [1-324](Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM77059(US10245267, Example 9 | US10709712, Example 9 | US...)copy SMILEScopy InChI
Affinity DataIC50: 0.900nMpH: 7.5 T: 2°CAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2x final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MC8X6WUS Patent
TargetRAF proto-oncogene serine/threonine-protein kinase [1-324](Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM202699(US10245267, Example 45 | US10709712, Example 45 | ...)copy SMILEScopy InChI
Affinity DataIC50: 1.02nMpH: 7.5 T: 2°CAssay Description:Final assay conditions were 4 pM cRaf, 3 uM ATP, 10 nM biotin tagged MEK1 kinase dead protein substrate. Reactions were performed in Greiner384 well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VT1QXTUS Patent
TargetRAF proto-oncogene serine/threonine-protein kinase [1-324](Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM202699(US10245267, Example 45 | US10709712, Example 45 | ...)copy SMILEScopy InChI
Affinity DataIC50: 1.02nMpH: 7.5 T: 2°CAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2x final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MC8X6WUS Patent
TargetRAF proto-oncogene serine/threonine-protein kinase [1-324](Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM202662(US10245267, Example 7 | US10709712, Example 7 | US...)copy SMILEScopy InChI
Affinity DataIC50: 1.11nMpH: 7.5 T: 2°CAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2x final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MC8X6WUS Patent
TargetRAF proto-oncogene serine/threonine-protein kinase [1-324](Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM202662(US10245267, Example 7 | US10709712, Example 7 | US...)copy SMILEScopy InChI
Affinity DataIC50: 1.11nMpH: 7.5 T: 2°CAssay Description:Final assay conditions were 4 pM cRaf, 3 uM ATP, 10 nM biotin tagged MEK1 kinase dead protein substrate. Reactions were performed in Greiner384 well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VT1QXTUS Patent
TargetRAF proto-oncogene serine/threonine-protein kinase [1-324](Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM202846(US10245267, Example 199 | US10709712, Example 199 ...)copy SMILEScopy InChI
Affinity DataIC50: 1.29nMpH: 7.5 T: 2°CAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2x final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MC8X6WUS Patent
TargetRAF proto-oncogene serine/threonine-protein kinase [1-324](Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM202846(US10245267, Example 199 | US10709712, Example 199 ...)copy SMILEScopy InChI
Affinity DataIC50: 1.29nMpH: 7.5 T: 2°CAssay Description:Final assay conditions were 4 pM cRaf, 3 uM ATP, 10 nM biotin tagged MEK1 kinase dead protein substrate. Reactions were performed in Greiner384 well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VT1QXTUS Patent
TargetRAF proto-oncogene serine/threonine-protein kinase [1-324](Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM202657(US10709712, Example 2 | US9242969, 2 | US9694016, ...)copy SMILEScopy InChI
Affinity DataIC50: 2.95nMpH: 7.5 T: 2°CAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2x final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MC8X6WUS Patent
TargetRAF proto-oncogene serine/threonine-protein kinase [1-324](Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM202657(US10709712, Example 2 | US9242969, 2 | US9694016, ...)copy SMILEScopy InChI
Affinity DataIC50: 2.95nMpH: 7.5 T: 2°CAssay Description:Final assay conditions were 4 pM cRaf, 3 uM ATP, 10 nM biotin tagged MEK1 kinase dead protein substrate. Reactions were performed in Greiner384 well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VT1QXTUS Patent